Results 141 to 150 of about 9,735,717 (300)
Frontiers in Built EnvironmentThis study examines change order behavior in public road infrastructure as a two-stage process separating occurrence from conditional severity. Using an official dataset of 157 projects in Jordan (116 pre-policy, 41 post-policy), the analysis applies ...
Mohammed A. K. A. Al-Btoush +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Project governance : definition and framework [PDF]
, 2009 Project governance has become part of the project management vocabulary. As a formal definition of the term lacked, it has been used in various contexts that caused confusion and misunderstanding.
Steyn, Herman +1 more
core
Project Leadership and SocietyPoor performance is common in the delivery of large-scale transport infrastructure. Despite previous studies examining the management of transport megaprojects, there is a lack of systematic reviews on performance Controls and Accountability in ...
Jackson Sekasi +3 more
doaj +1 more source
Project Indicators for Enhancing Governance of Projects
Procedia Technology, 2014 AbstractGovernance of projects, programmes and portfolios is an increasing research area and practice, but it is not yet considered to be as mature as it happens with project management concepts and practices. This paper presents an intermediate result from an on-going multi case research study addressing the perceived relevance of different projects ...
openaire +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Ocean governance: the New Zealand dimension [PDF]
, 2012 The Oceans Governance project was funded by the Emerging Issues Programme, overseen by the Institute of Policy Studies at Victoria University of Wellington. Its primary goal is to provide interested members of the public and policymakers with a
Michael Vincent McGinnis
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Climate Governance Post-2012, Options for EU Policy-Making. CEPS Policy Brief No. 177, November 2008 [PDF]
, 2008 This Policy Brief focuses on three issues that are especially important in the long-term development of the climate regime: (a) the challenge of the fragmentation of negotiations and governance systems; (b) the challenge of steering and evaluating novel ...
Edenhofer, Ottmar +11 more
core