Results 151 to 160 of about 139,293 (301)
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Understanding Community Governance: A Global Perspective
, 2013 Since the global financial crisis of 2008, government institutions have had to change their approaches to community governance. Over recent years there has been much discussion on the impact of community governance within local communities.
Cooke, Ian G. +3 more
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Indicators of Good Governance: Developing an Index of Governance Quality at the LGU Level [PDF]
Governance is a complex concept. It includes the state’s institutions and structures, its decisionmaking process, its capacity to implement guidelines and the relationship between government officials and the public. Hence, this study attempts to develop
Manasan, Rosario G. +2 more
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Exploring governance uncertainty in a complex information systems project
, 2016 It is well known that effective governance practices improve information systems (IS) project outcomes. Broadly speaking, we know that effective governance practices involve the right people having the right knowledge at the right time.
Smidt, Michelle +3 more
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FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
The infusion after the bolus: a quality improvement programme to support emergency department airway governance in Ireland. [PDF]
Emerg Med JLee J +5 more
europepmc +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Governance matters VIII : aggregate and individual governance indicators 1996-2008 [PDF]
This paper reports on the 2009 update of the Worldwide Governance Indicators (WGI) research project, covering 212 countries and territories and measuring six dimensions of governance between 1996 and 2008: Voice and Accountability, Political Stability ...
Kraay, Aart +2 more
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