Results 111 to 120 of about 13,048,775 (285)

Governance Mechanisms as Substitutes and Complements: Explaining Differential Relationships between Contractual and Relational Governance [PDF]

, 2010
In recent years scholars have discussed the relationship of contractual and relational governance in information systems outsourcing. For a long time the substitutional view of governance mechanisms originating from transaction cost theory was dominant ...
Fischer, Thomas A., Huber, Thomas, Huber, Thomas L., Fischer, Thomas   +3 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Enhancing IT Project Sustainability: The Role of Collaborative Resources, Stakeholder Engagement, and Project Governance

Business Review
The purpose of this research is to examine the impact of collaborative social resources on project sustainability in Pakistan's IT Projects, with particular emphasis on the mediating effect of stakeholder engagement and the moderating role of project ...
Laiba Tahir, Arif Uddin
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A Survey of Corporate Governance in Russia [PDF]

In this survey, we describe the current state of corporate governance in Russia and discuss its dynamics and prospects. We review the main mechanisms of corporate governance in the country and relate them to firms’ ownership structures, financial market ...
Olga Lazareva, Sergey Stepanov, Andrei Rachinsky   +2 more
core  

Synergistic development mechanism of discipline construction and postgraduate education driven by doctoral programme project construction-a case study of Zhongyuan University of Technology

Frontiers in Education
From a meso-level governance perspective, this study explores the synergistic pathways between discipline construction and postgraduate education under the doctoral project construction based on an analysis of their synergistic theoretical logic and ...
Huifan Zheng, Xuesong Zhang, Kun Qi, Fang Li, Jialin Liu, Boyang Qu, Yanqiu Xiao   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Network governance work: evidence from the video game industry [PDF]

Many call for research invites for further investigation of the underlying processes, practices and specificities of governance in the network context. Through an examination of what governance involves and how does it occur in a French cluster of video ...
Chahira Mehouachi, Véronique Perret
core  

Deconstructing synergistic carbon reduction mechanisms in large-scale construction governance: A Monte Carlo simulation based on a cross-scale model

Ain Shams Engineering Journal
This study develops a cross-scale collaborative optimization model to explore synergistic carbon emission reduction (SCER) mechanisms in governance networks for large-scale construction projects.
Zhizhe Zheng, Yikun Su, Junhao Liu
doaj   +1 more source