Results 91 to 100 of about 46,567 (296)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The influence of governance and complexity on project outcomes in international development [PDF]

, 2023
In this study, the impact of governance on the outcomes of international development projects is assessed and role of complexity in moderating this relationship is explored.
Javad, Bakhshi
core  

Synergistic development mechanism of discipline construction and postgraduate education driven by doctoral programme project construction-a case study of Zhongyuan University of Technology

Frontiers in Education
From a meso-level governance perspective, this study explores the synergistic pathways between discipline construction and postgraduate education under the doctoral project construction based on an analysis of their synergistic theoretical logic and ...
Huifan Zheng, Xuesong Zhang, Kun Qi, Fang Li, Jialin Liu, Boyang Qu, Yanqiu Xiao   +6 more
doaj   +1 more source

Women, Water Resource Management, and Sustainable Development: The Turkey-North Cyprus Water Pipeline Project

Resources, 2018
Women’s role in water resource management is recognized, yet the implementation of methods and strategies to get beyond gender-based obstacles to women’s equal participation in water resource management related projects remain vague ...
Emine Eminel Sülün
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Corporate governance: The artificial intelligence’s challenge — A research project

Artificial intelligence (AI) is an epochal challenge. We illustrate a research project concerning a particular field of its application: its use and its impacts in the accounting and business administration field and, more specifically, on corporate ...
Fradeani, Andrea
core   +1 more source

Disclosure Quality, Corporate Governance Mechanisms and Firm Value [PDF]

, 2016
One of the main aims of the underlying research is to respond to continuous calls for introducing and measuring a sound economic definition for best practice disclosure quality (e.g. Beyer et al., 2010) that is derived from a reliable guidance framework (
Anis, Radwa Magdy Mohamed
core  

Deconstructing synergistic carbon reduction mechanisms in large-scale construction governance: A Monte Carlo simulation based on a cross-scale model

Ain Shams Engineering Journal
This study develops a cross-scale collaborative optimization model to explore synergistic carbon emission reduction (SCER) mechanisms in governance networks for large-scale construction projects.
Zhizhe Zheng, Yikun Su, Junhao Liu
doaj   +1 more source

The allocation mechanism of authority and accountability in Chinese government hierarchies: A case study of the “Earmarked Project System”

The Journal of Chinese Sociology, 2017
Basado en teorías organizacionales básicas, este documento revisa los estudios sobre las relaciones intergubernamentales en China y propone un marco de explicación sistemático desde la perspectiva del mecanismo de asignación de autoridad y rendición de cuentas.
Shi, Puyuan, Ni, Mengwei
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source