Results 81 to 90 of about 46,567 (296)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Transition of Governance in a Mature Open Software Source Community: Evidence from the Debian Case [PDF]

As flourishing, productive open source software (OSS) communities mature, they have to introduce a variety of governance mechanisms to manage the participation of their members and to coordinate the launch of new releases.
Sadowski-Rasters, Gaby, Duysters, Geert, Sadowski, Bert   +2 more
core  

Factors influencing sustainability performance in public-private partnerships for transportation in China

Discover Sustainability
Achieving the sustainability goals of transportation Public-Private Partnership (PPP) projects in China remains a pressing challenge. Project governance mechanisms play a crucial role in advancing the sustainable development of such projects.
Shuangyu Yang, Supit Boonlab, Wanjai Lamprom   +2 more
doaj   +1 more source

Environmental governance in railway megaprojects: a stakeholder framework and validated empirical model

Transportation Research Interdisciplinary Perspectives
Environmental risks routinely delay, inflate, and discredit railway megaprojects, yet guidance on how to govern these risks remains fragmented and sector-agnostic.
Jackson Sekasi, Steven Harrod, Victor Andrade   +2 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

China’s blue carbon governance for sustainable development: ecological differentiation, policy architecture, and implementation pathways

Frontiers in Marine Science
Blue carbon ecosystems—mangroves, salt marshes, and seagrass beds—sit at the intersection of climate mitigation, coastal adaptation, biodiversity conservation, and sustainable development.
Yan Zheng, Hefeng Wang, Yangyi Ai, Yuanjun Wang, Jian Zhang, Jiarui Li   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Factors Affecting Internal Auditors' Ethical Decision Making: Other Corporate Governance Mechanisms and Years of Experience

, 2006
This project explores the ethical reasoning of internal auditors and examines the impact of other corporate governance \ud mechanisms on their ethical sensitivity, judgments and intentions.
O'Leary, Conor, Stewart, Jenny D., Stewart, Jenny   +2 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Enhancing IT Project Sustainability: The Role of Collaborative Resources, Stakeholder Engagement, and Project Governance

Business Review
The purpose of this research is to examine the impact of collaborative social resources on project sustainability in Pakistan's IT Projects, with particular emphasis on the mediating effect of stakeholder engagement and the moderating role of project ...
Laiba Tahir, Arif Uddin
doaj   +1 more source