Results 61 to 70 of about 41,566 (255)

Governance, contracts, and culture: A triadic approach to megaproject performance

Project Leadership and Society
Despite their transformative ambitions, transport megaprojects, such as high-speed rail systems, often underperform. This study investigates the California High-Speed Rail Project (CAHSRP) using a critical realist methodology and a Context-Mechanism ...
Jackson Sekasi, Steven Harrod, Victor Andrade   +2 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Asymmetric collaborative governance in Indonesia’s new capital: A quasi–public–private partnership approach to regional financial institution engagement [PDF]

International Journal of Human Capital in Urban Management
BACKGROUND AND OBJECTIVES: This study examined the implementation of the BPD Kaltimtara headquarters project in Indonesia’s New Capital City (Ibu Kota Nusantara/IKN) as a pioneering quasi-public-private partnership (quasi-PPP) model.
E. Maradona, B. Ngarawula, T. Hariyanto
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Assessing the role of territorial governance in the success of territory projects: A case study of the Fez craft industry

Moroccan Journal of Quantitative and Qualitative Research
Territorial governance has become omnipresent in all economic, political or social discourses, it is a question of implementing dynamic processes of coordination, pooling efforts, shared visions of different actors of a territory and diverse resources ...
saarra boutahar, Bouchra Debbagh
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Risk Management and Governance in Blockchain-Based Digital Identity Projects: A Business Analysis and Project Management Framework

ITEGAM-JETIA
Blockchain is viewed as a revolutionary solution to digital identity management, offering decentralization, security, and user control over one’s own private identity.
Tobiloba Kazeem, Olatoye Kabiru Agboola, Nonso Okika, Soyingbe Folasade Owoola-Adebayo, Fope Opeola, Nnenna Linda Akunna, Oreoluwa Serifat Abimbola   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Impact of Contractual Governance on Project Performance in Urban Sewage Treatment Public–Private Partnership Projects: The Moderating Role of Administrative Efficiency

Buildings
In public–private partnership (PPP) projects, the private sector’s performance is influenced by administrative efficiency, and the impact varies across different contractual dimensions.
Jialin Gui, Jinbo Song, Wen Xia
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source