Results 61 to 70 of about 13,048,775 (285)

Urban Lifeline Security Projects: Research on the Holistic Governance Model of Urban Public Security Empowered by Digital Technology

Smart Cities
With the rapid advancement of urbanization, the density and vulnerability of urban lifeline networks are increasing, and urban lifeline security risks have become a major challenge to urban public security governance.
Qi Zou, Shuai Liu, Hongyong Yuan, Jiaojiao Liu   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The effect of governance and governmentality on project portfolio success

Acta Commercii
Orientation: Although project portfolio is a renowned tradition in organisations, its effective management remains a challenge. Research purpose: The aim of the study was to investigate the effect of governance and governmentality on project portfolio ...
Joseph S. Mohosho, Kwete Mwana Nyandongo, Shopee Dube   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Independent accountability mechanisms: Promotion of standards, good governance and accountability

Since 1993, international accountability mechanisms (IAMs) have been established by international financial institutions (IFIs) including the World Bank and regional development banks to handle problem projects which adversely impact on people.
Nanwani, Suresh, McIntyre, Owen
core   +1 more source

Research into a BIM-based transparency and trust mechanism for the Irish construction supply chain: a pathway to systemic delivery

Frontiers in Built Environment
IntroductionLarge-scale public infrastructure projects in Ireland consistently face cost overruns and delivery delays, yet research has not fully clarified how digital systems function as governance mechanisms rather than mere coordination tools.
Geni Zhang, Seong Mok Paik
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Operationalizing sustainability through contracts and relational governance in technology driven HVAC projects

Discover Sustainability
Achieving project sustainability is a strategic imperative that integrates core business functions. This study examines how Contractual Governance (formal agreements) and Relational Governance (informal trust) enhance sustainability in Heating ...
Muhammad Sajjad, Muhammad Sajid, Adnan Hushmat, Rabia Abrar, Aitizaz Ali, Nadeem Sarwar   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source