Results 41 to 50 of about 41,566 (255)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The effect of governance and governmentality on project portfolio success

Acta Commercii
Orientation: Although project portfolio is a renowned tradition in organisations, its effective management remains a challenge. Research purpose: The aim of the study was to investigate the effect of governance and governmentality on project portfolio ...
Joseph S. Mohosho, Kwete Mwana Nyandongo, Shopee Dube   +2 more
doaj   +1 more source

Hard and soft governance mechanisms for large projects. A historical perspective

Journal of Management History
Purpose Drawing motivation from the greater exposure to uncertainty and condition changes that affect large projects due to their long lifecycle, this paper aims to investigate how the time factor affects the use of governance mechanisms to pursue the success of these projects.
GIORGINO MARIA CLEOFE, BARNABE' FEDERICO
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Research into a BIM-based transparency and trust mechanism for the Irish construction supply chain: a pathway to systemic delivery

Frontiers in Built Environment
IntroductionLarge-scale public infrastructure projects in Ireland consistently face cost overruns and delivery delays, yet research has not fully clarified how digital systems function as governance mechanisms rather than mere coordination tools.
Geni Zhang, Seong Mok Paik
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Operationalizing sustainability through contracts and relational governance in technology driven HVAC projects

Discover Sustainability
Achieving project sustainability is a strategic imperative that integrates core business functions. This study examines how Contractual Governance (formal agreements) and Relational Governance (informal trust) enhance sustainability in Heating ...
Muhammad Sajjad, Muhammad Sajid, Adnan Hushmat, Rabia Abrar, Aitizaz Ali, Nadeem Sarwar   +5 more
doaj   +1 more source

Development of a data-driven urban immunity assessment model: providing a new benchmark for urban governance under public health emergencies

Frontiers in Public Health
Public health emergencies (PHEs) pose significant challenges to global urban governance systems, necessitating the establishment of more efficient and dynamically adaptive response mechanisms.
Peng Cui, Peng Cui, Saiya Cao, Ruize Qin, Fan Zhang   +4 more
doaj   +1 more source