Results 151 to 160 of about 46,567 (296)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

How to Measure Governance in Forestry: Key Dimensions and Indicators from Emerging Economic Mechanisms.

, 2010
In the current debate and analysis on new forms of governance, the attention is rarely focused on the instruments to assess “good governance” effects. A well-consolidated system of indicators for measuring governance does not exist in forestry yet. World-
DA RE, RICCARDO, SECCO, LAURA, GATTO, PAOLA, TAKU TASSA D.   +3 more
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Governance Processes, Employee Voice and Performance Outcomes in the Construction of Heathrow Terminal 5 [PDF]

The Major Projects Agreement (MPA) is a framework agreement designed to improve performance in large mechanical and electrical engineering projects.
Aristea Koukiadaki, Simon Deakin
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

SOME ARGUMENTS THAT JUSTIFY THE AUDIT TRINITY’S APPROACH IN THE CONTEXT OF CORPORATE GOVERNANCE [PDF]

The purpose of this paper is to develop a synthesis of the main arguments that could justify the necessity of audit trinity’s approach (internal audit, external audit, audit committee) in assuring good corporate governance.
Cristina Bota-Avram
core  

From Pilot Trap to Institutional Capacity: A Governance Framework for Sustainable Clinical AI Implementation in Health Systems. [PDF]

J Med Internet Res
Tian J, Zhao Z, Tang L, Song Y, Li Y, Jiang N.   +5 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Governance Models and Partnerships in the Urban Water Sector: A framework for analysis and evaluation

, 2014
This working paper is part of a research project on governance models and partnerships in water supply and wastewater management in urban areas. The project is a collaboration between Utrecht University and Tilburg University, both of which are located ...
Frankowski, A.F.S., van Montfort, C.J., UU LEG Research USG Public Matters, LS Bestuurkunde, van Montfort, Cor, Michels, A.M.B., UU LEG Research USG Public Matters Public Governance and Management, Frankowski, Andrea, van Montfort, C.J.; id_orcid, Michels, Ank   +9 more
core  

When formal governance persists but resilience does not: health system governance and resilience in Yemen across a decade of conflict and crisis (2014-2025). [PDF]

BMC Health Serv Res
Hyzam D, Boah M, Dhaiban M, Dureab F, Al-Mahbashi T, Hadi A, Al Sakkaf K, Feldmann G, Ulrichs T.   +8 more
europepmc   +1 more source