Results 91 to 100 of about 752,931 (266)

The East African Community (EAC) mobile laboratory networks in Kenya, Burundi, Tanzania, Rwanda, Uganda, and South Sudan-from project implementation to outbreak response against Dengue, Ebola, COVID-19, and epidemic-prone diseases. [PDF]

BMC Med, 2021
Affara M, Lagu HI, Achol E, Karamagi R, Omari N, Ochido G, Kezakarayagwa E, Kabatesi F, Nkeshimana A, Roba A, Ndia MN, Abudo MU, Kabanda A, Mpabuka E, Mwikarago EI, Kutjok PE, Samson DD, Deng LL, Moremi N, Kelly ME, Mkama PBM, Magesa A, Balinandi SK, Pimundu G, Nabadda SN, Puradiredja DI, Hinzmann J, Duraffour S, Gabriel M, Ruge G, Loag W, Ayiko R, Sonoiya SS, May J, Katende MJ, Gehre F.   +35 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Effect of Next Generation Fertilizers on Growth and Yield Potential of Maize (Zea mays L.)

International Journal of Economic Plants, 2020
To reduce the existing yield gap of maize crop between research and farmer’s field, the experiment was carried out during the period from March, 2014 to June, 2014 at the experimental field of Sher-e-Bangla Agricultural University, Sher-e-Bangla Nagar ...
M. A. A. Faroque, Alok Kumar Paul, Asaduzzaman, Parimal Bissus, M. S. Islam   +4 more
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Analysis of problem feedback and treatment mechanism in process of informatization project implementatio

Gong-kuang zidonghua, 2013
Inview of particularity of informatization project of a coal enterprises, taking informatization project in a coal enterprise as an example, the paper analyzed existed problems in process of project implementation, put forward some objective and ...
TAN Zhang-lu, CHANG Jin-ming, LIU Hao
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Exploring the lived experiences of menstrual hygiene management among in-school visually impaired adolescent girls in rwanda: a phenomenological study

Discover Public Health
Background In low-income countries, many menstruating persons continue to face numerous challenges regarding menstrual hygiene management. Visual impairment further compounds the difficulties faced by in-school adolescent girls, but little is known about
Marie Laetitia Ishimwe Bazakare, Gerard Kaberuka, Aimable Nkurunziza, Justine Bagirisano, Jean Bosco Henri Hitayezu, Yvonne Delphine Nsaba Uwera, Juliet Mukankusi, Godfrey Katende, David Ntirushwa, Donatilla Mukamana, Michael Habtu   +10 more
doaj   +1 more source

Wellness project implementation within Houston's Faith and Diabetes initiative: a mixed methods study. [PDF]

BMC Public Health, 2020
Wells R, Breckenridge ED, Linder SH.
europepmc   +1 more source