Results 61 to 70 of about 13,220,351 (194)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Review and evaluation of the Inquiry to Implementation Project final report 2014 [PDF]

, 2014
The inquiry based professional learning project, Inquiry to Implementation was developed by the Victorian Curriculum and Assessment Authority (VCAA) as a key professional learning resource to support implementation of the Victorian Early Years Learning ...
Marilyn Fleer, Linda Harrison, Iris Duhn
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The "Reducing the Impact of Sexual Exploitation" (RISE) Project: An Implementation evaluation [PDF]

, 2019
This project reports on the implementation evaluation of a two year pilot "Reducing the Impact of Sexual Exploitation (RISE)", that ran in Aberdeen and Dundee.
Beetham, Tanya, Callaghan, Jane, Rigby, Paul   +2 more
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The project of state transforma- tions by M.M. Speransky

Вестник Майкопского государственного технологического университета
The relevance of the research lies in the analysis of the transformation project of one of the outstanding reformers of the days of Alexander I, whose ideas were not duly appreciated, but could prevent serious upheavals in Russia during subsequent reigns.
M. A. Aleksenko, A. N. Popov, O. Yu. Malakhovа   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Strategy for soil and water management in the Thames River Basin

, 1982
This report presents a summary of the Thames River Implementation Committee program and discusses the key program recommendations related to policy, community education, land use management and conservation practices.Ontario Ministry of the ...
Thames River Implementation Committee
core   +1 more source

Exploring New Barriers to the Implementation of Frugal Innovation Projects Among Spanish Ngdos

Quaestiones Geographicae
The concept of frugal innovation has attracted significant academic interest over the last decade, but its diffusion among non-governmental organisations (NGOs) with technology transfer programmes in the Global South has been insufficiently examined ...
Rodríguez Beatriz Delfa, Gomez Georgina M., Ballesteros Carlos   +2 more
doaj   +1 more source