Results 251 to 260 of about 15,410,907 (366)

Epigenome‐wide association study, meta‐analysis, and multiscore profiling of whole blood in Parkinson's disease

open access: yesAnnals of Clinical and Translational Neurology, Volume 12, Issue 4, Page 701-713, April 2025.
Abstract Objectives An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation in Parkinson's disease and to evaluate the biomarker potential of methylation‐based ...
Ingeborg Haugesag Lie   +4 more
wiley   +1 more source

Relationship of cognitive decline with glucocerebrosidase activity and amyloid‐beta 42 in DLB and PD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Dementia with Lewy bodies (DLB) and Parkinson's disease (PD) share clinical, pathological, and genetic risk factors, including GBA1 and APOEε4 mutations. Biomarkers associated with the pathways of these mutations, such as glucocerebrosidase enzyme (GCase) activity and amyloid‐beta 42 (Aβ42) levels, may hold potential as predictive ...
Maria Camila Gonzalez   +15 more
wiley   +1 more source

FragMAXapp: crystallographic fragment-screening data-analysis and project-management system. [PDF]

open access: yesActa Crystallogr D Struct Biol, 2021
Lima GMA   +8 more
europepmc   +1 more source

Genotype‐function‐phenotype correlations for SCN1A variants identified by clinical genetic testing

open access: yesAnnals of Clinical and Translational Neurology, Volume 12, Issue 3, Page 499-511, March 2025.
Abstract Objective Interpretation of clinical genetic testing, which identifies a potential genetic etiology in 25% of children with epilepsy, is limited by variants of uncertain significance. Understanding functional consequences of variants can help distinguish pathogenic from benign alleles.
Andrew T. Knox   +6 more
wiley   +1 more source

Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study

open access: yesAnnals of Clinical and Translational Neurology, Volume 12, Issue 4, Page 746-755, April 2025.
Abstract Objective Idiopathic intracranial hypertension (IIH) is a neurological disorder predominantly affecting young women with obesity, characterized by elevated intracranial pressure. While current treatments include weight loss counseling, medical therapies, and surgical interventions, their limitations necessitate exploring novel therapeutic ...
Ahmed Y. Azzam   +13 more
wiley   +1 more source

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