Results 51 to 60 of about 5,104,399 (355)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Analysis of the Available Project Management Methodologies

Management, 2018
The paper is an analysis of the available project management methodologies from the standpoint of their applicability. Our aim is to establish specific characteristics of the today available methodologies (PMS, APM, PRINCE2, YUPMA, etc.) that can ensure
Petar Jovanovic, Ivana Beric
doaj   +1 more source

Integration of Cost andWork Breakdown Structures in the Management of Construction Projects [PDF]

, 2020
Scope management allows project managers to react when a project underperforms regarding schedule, budget, and/or quality at the execution stage. Scope management can also minimize project changes and budget omissions, as well as improve the accuracy of ...
Anticona, Aziz, Bartlett, Buchtik, Byrne, Büchmann-Slorup, Camilleri, Cantarelli, Cerezo-Narváez, Cerezo-Narváez, Chrissis, Cooper, Desmond, George, Globerson, González Fernández de Valderrama, Gómez-Senent Martínez, Hair, Hansen, Harrison, Heerkens, Hendrickson, Ho, Hooper, Hughes, Jawad, Kaiser, Kerzner, Khan, Kim, Kline, Kraus, Lee, Liberzon, Lister, Lock, López Paredes, Marsh, Mhetre, Nam, Nayak, Nouban, Park, Pavan, Tabachnick, Taner, Taylor, Teicholz, Thaweejinda, Vahed, Wang, Washington, Yang, Young-Bae   +53 more
core   +2 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Impact of irrigation and crop residue management on maize (Zea mays)– chickpea (Cicer arietinum) sequence under no tillage conditions

The Indian Journal of Agricultural Sciences, 2014
A field experiment was conducted during 2007-08 and 2010-11 at Belvatagi, Karnataka to study the effect of irrigation and crop residue mulching on water use efficiency and yield of maize (Zea mays L.) - chickpea (Cicer arietinum L.) sequence under no ...
S RAJKUMARA, S S GUNDLUR, J K NEELAKANTH, P ASHOKA   +3 more
doaj   +1 more source

Development of multifunctional software for business operations in SMEs [PDF]

Tehnika, 2016
This paper presents the web-oriented software solution focused on supporting the efficient management of operations and projects in SMEs. The development of this software is treated as a separate project and has used agile software development ...
Berić Ivana M., Jovanović Aca D., Popović Milan M., Radulović Aleksandar V.   +3 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Modeling of combat operations

Vojnotehnički Glasnik, 2023
Introduction/purpose: The goal of the research in this paper is to present and evaluate the method of modeling operations by aggregating forces by simulating the battle process with Lanchester's equations.
Mladen S. Kostić, Aca D. Jovanović, Mitar V. Kovač   +2 more
doaj   +1 more source

Project regularity : development and evaluation of a new project characteristic [PDF]

, 2017
The ability to accurately characterize projects is essential to good project management. Therefore, a novel project characteristic is developed that reflects the value accrue within a project.
Batselier, Jordy, Vanhoucke, Mario
core   +2 more sources