Results 81 to 90 of about 3,089,193 (316)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Twelve month prospective study of snakebite in a major teaching hospital in Mandalay, Myanmar; Myanmar Snakebite Project (MSP)

Toxicon: X, 2019
The Myanmar Snakebite Project is an Australian government (Department of Foreign Affairs and Trade) supported foreign aid project in collaboration with the Myanmar government with the aim of improving outcomes for snakebite patients in Myanmar.
Julian White, Sam Alfred, David Bates, Mohammad Afzal Mahmood, David Warrell, Robert Cumming, Khin Thida Thwin, Myat Myat Thein, Myo Thant, Zaw Myo Naung, Ye Htet Naing, Su Sint Sint San, Myat Thet Nwe, Chen Au Peh   +13 more
doaj   +1 more source

Automatic Analyzer for Iterative Design [PDF]

, 1969
The Office of Naval Research Department Of The Navy Contract Nonr 1834 (03) Project NR-064 ...
Ertas, Rebii, Fenves, S.J.
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Designing methodology on the basis uses miсrоsоft office project

RUDN Journal of Informatization in Education, 2011
In article the approach of formation of abilities of designing on the basis of use Miсrоsоft Office Project is considered. The basic concepts necessary for mastering of designing in Miсrоsоft Office Project are allocated. The technique of creation of the
A S Zaharov
doaj  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Detached house with project office [PDF]

, 2016
Předmětem bakalářské práce je samostatně stojící novostavba rodinného domu s projekční kanceláří. Jednotlivé funkční části mají samostatný vchod a nejsou dispozičně propojeny.
Váňa, Jan
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Low Measles Vaccination Coverage and Spatial Analysis of High Measles Vaccination Dropout in Ethiopia’s Underprivileged Areas

Vaccines
(1) Background: Measles remains a major cause of disease and death worldwide, especially in the World Health Organization African Region. This study aimed to estimate the coverage of measles vaccinations and map the spatial distribution of measles ...
Fisseha Shiferie, Samson Gebremedhin, Gashaw Andargie, Dawit A. Tsegaye, Wondwossen A. Alemayehu, Teferi Gedif Fenta   +5 more
doaj   +1 more source

The youth need chemistry, chemistry needs the youth

LUMAT, 2013
During ChemBio 2013 event there was a panel discussion under the topic ”What the youth need chemistry for?” From the viewpoint of chemical industry, the answer is clear.
Riitta Talvenlahti
doaj   +1 more source