Results 171 to 180 of about 1,342,681 (265)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Local performance and fairness testing of an AI Scribe in a paediatric developmental assessment clinic in South Australia: a silent trial protocol. [PDF]

BMJ Open
McCradden MD, Tng S, Jeyaseelan D, Leane C, Campbell M, Braund T, Earle-Bandaralage L, Ebrahimi M, Sharma A, Tang J.   +9 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Data of short-term thermal energy storage strategy with medium-deep borehole heat exchanger. [PDF]

Data Brief
Liu J, Wang R, Zhang S, Fang Z.
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

The wisdom of crowds emerges in flocks of thousands of migrating songbirds. [PDF]

Sci Adv
Morford J, Lewin PJ, Wynn J, Belotti MCTD, Mann RP, Krupenye C, Biro D.   +6 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Project performance diagnostics : a model for assessing construction project performance in Nigeria

Construction Projects are notorious for demonstrating poor performance and under achievement as usually indicated by project objectives. Project managers in the construction industry are faced with many research suggestions in literatures to improve performance but there are confusion in the implementation of these recommendations.
openaire  

Gait asymmetry as a determinant of functional recovery and return to sport after ACL reconstruction: a cross-sectional biomechanical analysis. [PDF]

Front Bioeng Biotechnol
Alhefzi AI, Reddy RS, Alfaya FF, Alshehri SHS, Mukherjee D, Alkhamis BA, Ahmad I, Kardm S, Koura GM, Al Salim Z, Gautam AP, Alyazedi FM, Samir SM, Fathi Elshiwi AM, El Melhat AM.   +14 more
europepmc   +1 more source