Results 61 to 70 of about 1,202,578 (267)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Exploring the China-Pakistan economic corridor project performance during Covid-19 pandemic. [PDF]

Heliyon, 2023
Mahmood S, Sun H, Abdein MA, Qadri SU, Iqbal A, Abdelkader MFM, Mahmoud MH, Hewedy O.   +7 more
europepmc   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Blockchain-smart contracts for sustainable project performance: bibliometric and content analyses. [PDF]

Environ Dev Sustain, 2023
Cheng M, Chong HY, Xu Y.
europepmc   +1 more source

Probing the Effect of Business Intelligence on the Performance of Construction Projects Through the Mediating Variable of Project Quality Management

Buildings
Business intelligence is a new approach to helping project managers and personnel to make correct, informed decisions through preparing a series of analytical reports in a management dashboard by analysing and mining all of the related project data. This
Mahboobeh Golestanizadeh, Hadi Sarvari, Amirhossein Parishani, Nelson Akindele, David J. Edwards   +4 more
doaj   +1 more source

Exploring the consequences of human multitasking in industrial automation projects: a tool to mitigate impacts – Part II

Organization, Technology and Management in Construction: An International Journal, 2018
Each industrial automation project includes tasks that strongly depend on human factors, many of which may belong to the critical path or chain of the project. Multitask­ing significantly affects human productivity.
Petroutsatou Kleopatra, Sifiniadis Anestis   +1 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Linking Knowledge Heterogeneity with Project Performance in Digital Project Teams: The Role of Digital Capability and Knowledge Conversion. [PDF]

J Knowl Econ, 2023
Liu H, Li J, Liu L.
europepmc   +1 more source

Project characteristics, project management software utilization and project performance: An impact analysis based on real project data

International Journal of Information Systems and Project Management, 2022
Project management software packages are increasingly used by companies. These tools require a substantial financial investment, hence the importance of identifying the real contribution of project management software packages to the realization of ...
Robert Pellerin, Nathalie Perrier, Xavier Guillot, Pierre-Majorique Léger   +3 more
doaj  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source