Results 51 to 60 of about 3,216,977 (346)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Data driven planning and approval processes of public road construction projects [PDF]
, 2023 Jonathan Matthei +1 more
openalex +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Communications Earth & EnvironmentMany valuable economic benefits from nature have traditionally been overlooked in both national accounts and government policy. To remedy this, countries are adopting the new United Nations System of Environmental-Economic Accounting framework for ...
Lisa Mandle +7 more
doaj +1 more source
Town of Chester Stormwater Management Project [PDF]
, 2008 Great Bay Environmental Consulting (GBEC) worked with the Town of Chester Planning Board to improve regulatory approaches to stormwater management.
NHEP Community Technical Assistance Program
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
A study of project planning on Libyan construction projects [PDF]
, 2008 Construction projects are regularly faced by scheduling problems causing the projects to finish beyond their predetermined due date; this is a global phenomenon.
Abubaker, Ali +2 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Adaption of structured analysis design techniques methodology for construction project planning [PDF]
, 2012 The construction industry has been heavily criticised by researchers and governmental organisations for its performance especially excessive delay. Ballard and Howell (2003) indicated that only about 50% of the tasks on weekly work plans are completed by
Agyekum-Mensah, G +2 more
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