Results 61 to 70 of about 3,216,977 (346)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Deep Geothermal Energy Production in Germany
Energies, 2014 Germany uses its low enthalpy hydrothermal resources predominantly for balneological applications, space and district heating, but also for power production.
Thorsten Agemar +2 more
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Energies, 2018 The research on carbon capture and storage (CCS) project planning and investment and operational decision-making can provide a reference for enterprises to invest in CCS and for policy-makers to formulate policies to promote CCS development.
Jiaquan Li +3 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Simulation modelling construction project with repetitive tasks using Petri nets theory
Journal of Business Economics and Management, 2008 Resources selection and allocation at the project planning stage is an important issue for reducing project cost, duration and risk. Existing planning and scheduling methods overlook aspects of limited production capacity of construction companies ...
Sławomir Biruk, Piotr Jaśkowski
doaj +1 more source
Модели, системы, сети в экономике, технике, природе и обществе, 2022 Background. The article discusses the features of the functioning of projectoriented organizations in a competitive environment. The specifics of projects is described in which the main category of resources is specialists, and not material and ...
V.V. Kalevko, D.G. Lagerev
doaj +1 more source
River basin planning project: social learning (Science Report SC050037/SR1) [PDF]
, 2005 This report documents the findings of a 12-month Environment Agency science project on social learning for river basin planning. Our aim was to use social learning approaches and soft system methods to inform the development of the River Basin Planning ...
Blackmore, Chris +2 more
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