Results 151 to 160 of about 237,675 (304)

A Review and Mapping of Project Schedule Monitoring Methods

Schedule control is fundamental to project success, enabling proactive management of deviations from the baseline plan. While Earned Value Management (EVM) provides solid results for analyzing schedule performance, its limitations prompted the ...
Preziosa S., Ottaviani F. M., Narbaev T., De Marco A., Rebuglio M.   +4 more
core   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Early detection of construction project risks in Saudi Arabia: a mixed-methods study on warning signs and mitigation. [PDF]

Sci Rep
Alsulami BT, Al-Shaery AM, Kassem MA.
europepmc   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

A framework policy analysis of single-dose HPV vaccination adoption in East Africa: a rapid review. [PDF]

BMC Health Serv Res
Umutesi G, Weiner BJ, Jewell T, Kapiga S, Lane J, Mugo NR, Barnabas RV.   +6 more
europepmc   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Kalgoorlie nickel smelter furnace rebuild (KNS) project and Kalgoorlie nickel smelter expansion (KNE) project

, 2008
The Kalgoorlie Nickel Smelter (KNS) Furnace Rebuild Project and the Kalgoorlie Nickel Smelter Expansion (KSE) Project are both conducted by the contractor Fluor Australia Pty Ltd for the client BHP Billiton Nickel West. The Nickel Smelter is located on a
French, Rebecca Suzanne
core  

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

A comprehensive framework for evaluating bridge project rework through earned value management (EVM) and building information modeling (BIM). [PDF]

Sci Rep
Elseufy SM, Hussein A, Badawy M.
europepmc   +1 more source

PROJECT SCHEDULE OPTIMISATION FOR SAFETY MANAGEMENT IN CONSTRUCTION

, 2017
In construction project management, safety management processes are of capital importance for project success. Project schedule is the baseline for project control, therefore construction scheduling has to address safety related issues of construction ...
M. Bragadin, K. Kähkönen
core