Results 41 to 50 of about 198,428 (256)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

RESOURCES SUAINABILITY PLANNING MODEL USING HIERARCHICAL APPROACH FOR CONSTRUCTION PROJECT

Diyala Journal of Engineering Sciences, 2012
Within the early stages of construction project planning, resources restrictions are often neglected. Usually this leads to cost and schedule overruns.
ABBAS M. ABD
doaj   +1 more source

PENGENDALIAN WAKTU DAN BIAYA PELAKSANAAN PROYEK PEMBANGUNAN UNIT LAYANAN KANKER TERPADU RSUD BALI MANDARA

Jurnal Ilmiah Teknik Sipil, 2022
The construction of the Integrated Cancer Service Unit of Mandara Regional Hospital experienced a delay in employment in the 10th week of 1,16%, the 11th week of 2,58%, and the 12th week of 3,77%, so the project control action required to overcome the ...
Gusti Ayu Putu Candra Dharmayanti, Gede Astawa Diputra, Ni Putu Eka Rahayu Damayanthi   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Quantifying Schedule Delay Risk in Construction Projects: A Data-Driven Approach with BIM and Probabilistic Reliability Analysis

Advances in Civil Engineering, 2023
Progress management is an important scheme of construction management. In practical affairs, many unknown factors may lead to potential project delays and make the schedule risky.
Shen Zhang, Xingyu Wang
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Enhanced ESM approach for duration forecasting in delayed projects

Ain Shams Engineering Journal
Delays occur commonly for construction projects. How to control projects before delays are desired by project managers. The Earned schedule method (ESM), a derivative of the earned value management method, forecasts project durations effectively ...
Jyh-Bin Yang, Yu-Hsin Chen
doaj   +1 more source

Risk Propagation Model and Simulation of Schedule Change in Construction Projects: A Complex Network Approach

Complexity, 2020
Construction schedules play an important role in construction project management. However, during construction activities, risks may arise due to unexpected schedule changes, resulting in the ineffective delivery of projects.
Yusi Cheng, Jingfeng Yuan, Lei Zhu, Wei Li   +3 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source