Results 41 to 50 of about 237,675 (304)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Multi-Factor superposition influence analysis in engineering projects: a Bayesian network approach
Journal of Asian Architecture and Building EngineeringThe existing studies rarely examine whether multiple risk factors superimposed on a particular activity result in superposed or non-superposed effects.
Chaoyong Zhang, Keming Hu, Xun Liu
doaj +1 more source
Reactive project scheduling method to enhance project progress under uncertainty
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2016 This study proposes a new method for reactive project scheduling that enhances a smooth progress of a project, which is referred to as a “degree of project progress (DPP).” The proposed method generates a so called revision plan for the rest of a current
Haruhiko SUWA, Daisuke MORITA
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Nonlinear Engineering, 2022 In order to solve the problems of data acquisition, quantitative analysis and model solving in the field of construction schedule optimization, a construction schedule optimization system based on genetic algorithm was constructed.
Ren Yuan +4 more
doaj +1 more source
Linking partnering success factors to project performance - Findings from two nation-wide surveys
Project Leadership and Society, 2021 In this article we present findings from an investigation into the influence of partnering success factors on multi-partner projects’ abilities to meet time schedule, budget, and technical specifications.
Kristina Nevstad +5 more
doaj +1 more source