Results 91 to 100 of about 3,619,509 (312)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Interdisciplinary methodological approach to the process of brownfield revitalisation of traditional industrial areas [PDF]
Revija za Geografijo, 2011 Traditional industrial regions in the South-East Europe (SEE) represent an underexplored economic value. Revitalisation is delayed and hindered because of legal, financial, environmental and image problems.
Lučka Lorber, Ph.D., Assistant Professor
doaj
, 2021 In this article author reports about the results of a project work realized at the Óbuda University in Budapest (Hungary) in cooperation with Serbian students, who participated in Erasmus+ student exchange program based on bilateral agreement between the Óbuda University Sándor Rejtő Faculty of Light Industry and Environmental Engineering, Institute of
openaire +1 more source
Young Enterprise: Evaluating the impact of the Team programme [PDF]
, 2016 This report sets out the findings of the evaluation of the Team programme conducted by the International Centre for Guidance Studies at the University in 2016.
Hoare, Malcolm +3 more
core +1 more source
Reflections on the heuristic experiences of a multidisciplinary team trying to bring the PCA to participatory design (with emphasis on the IPR method) [PDF]
, 2015 This paper introduces a heuristic case study, reflecting on the use of the Interpersonal Process Recall (IPR) method as part of An Internet of Soft Things, a multidisciplinary design research project working with the UK mental health charity, Mind.
Bates, M, Kettley, R, Kettley, S
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Online naturalistic inquiry for stakeholder issue analysis: Design and implementation
Project Leadership and SocietySocial media offers extensive reach and inclusive engagement potential for projects and stakeholders. Current studies document its use for project information dissemination, building project awareness and project stakeholder assessment.
Jingbo Zhang, Kon Shing Kenneth Chung
doaj +1 more source
Methodology of social control of projects to improve the supervision of public works
, 2021 The main objective of this research was to design a methodology for the social control of projects to improve the supervision of public works in the entities of the Peruvian state. This research was of an applied type, it also had an explanatory level design, since it generated and evaluated the adequate implementation of the process flow chart ...
Calderón Paniagua, Dennys Geovani +1 more
openaire +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source