Results 101 to 110 of about 3,592,985 (311)
Endogenous Fishing Mortalities: a State-Space Bioeconomic Model [PDF]
, 2017 A methodology that endogenously determines catchability functions that link fi shing mortality with contemporaneous stock abundance is presented. We consider a stochastic age-structured model for a fishery composed by a number of fi shing units ...
Da Rocha, José María +3 more
core +3 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Online naturalistic inquiry for stakeholder issue analysis: Design and implementation
Project Leadership and SocietySocial media offers extensive reach and inclusive engagement potential for projects and stakeholders. Current studies document its use for project information dissemination, building project awareness and project stakeholder assessment.
Jingbo Zhang, Kon Shing Kenneth Chung
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Procedia - Social and Behavioral Sciences, 2013 AbstractTutoring is a methodological element of utmost importance in the EHEA (European Higher Education Area) context. Academic tutoring at university-level must offer counselling and technical support to university students in the three following areas: academic, professional and personal.
openaire +1 more source
LIFE: Costing the digital preservation lifecycle [PDF]
, 2007 Having confidence in the permanence of a digital resource requires a deep understanding of the preservation activities that will need to be performed throughout its lifetime, and an ability to plan and resource for those activities.
Ayris, Paul +4 more
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Development of a Degradation Model for the Collapse Analysis of Composite Aerospace Structures [PDF]
, 2006 For stiffened structures in compression the most critical damage mechanism leading to structural collapse is delamination or adhesive disbonding between the skin and stiffener.
Bayandor, Javid +4 more
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source