Results 121 to 130 of about 3,619,509 (312)

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Proposal for the implementation of BIM methodology in public works projects of Costa Rica

, 2020
Building Information Modeling (BIM) is a new methodology that has been growing in recent years within Costa Rica. However, this diffusion has generated isolated attempts, mainly from the private sector. In order to the current capability of the country in the use of the BIM, some interviews were distributed among the public, private and academic ...
Carmona Zúñiga, Mauricio, Mata Abdelnour, Erick   +1 more
openaire   +1 more source

PEER: Exploring the Lives of Sex Workers in Tyne and Wear [PDF]

, 2013
The overall aim of the PEER project is to provide a robust evidence base regarding the experiences andservice needs of women engaging in sex work in Tyne and Wear, in order to inform local knowledge, policyand practice in this area.
Irving, Adele, Laing, Mary
core  

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

ORGANIZATION OF SELF-INSTRUCTION WORK FOR STUDENTS OF TECHNICAL UNIVERSITY IN THE SYSTEM OF BASIC SCIENCE STUDIES

Высшее образование в России, 2016
Tomsk polytechnic university experience in organization of selfBinstruction work for bachelor and master degree students is discussed in the paper. SelfBinstruction work are organized on projectBbased cooperative learning methodology in studying physics -
Vitaliy V. Larionov, Andrey M. Lider
doaj  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Working Capital Exposure: A Methodology to Control Economic Performance in Production Environment Projects

, 2010
This paper evaluates the performance of 16 different parametric, nonparametric and one semi-parametric specifications to calculate the Value at Risk (VaR) for the Colombian Exchange Market Index (IGBC). Using high frequency data (10-minute returns), we model the variance of the returns using GARCH and TGARCH models, that take in account the leverage ...
Rivera Cadavid, Leonardo, Manotas Duque, Diego Fernando   +1 more
openaire   +1 more source

Teaching Work by Projects: communication perspectives and the teaching methodologies in the context of new technologies

, 2022
This article deals with a study on new technologies, educational communication and teaching methodology by projects. The interest in this topic is justified, because the didactic methodologies in the teaching and learning process, in the face of the accelerated advance of new digital technologies, are among the biggest challenges of the teacher, in ...
Prados, Rosália, de Sousa Lamas, Juliana   +1 more
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

DESIGNING A WEBSITE FOR A RECRUITMENT AGENCY WITH PMBOK METHODOLOGY [PDF]

Buletin ştiinţific: Universitatea din Piteşti. Seria Ştiinţe Economice, 2018
Project management refers to a set of activities that contribute to to achieve a successful project: defining the objectives, establishing the team, planning the tasks and providing the resources and deadlines for completing them, continuous assessing ...
Logica BANICA, Alina HAGIU, Alexandra BAGESCU, Andrei GHERGHINESCU   +3 more
doaj