Results 141 to 150 of about 3,619,509 (312)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Proposing a quantitative index to measure the industrialisation level of building projects

Results in Engineering
The industrialisation of construction has been the subject of numerous studies that aim to enhance efficiency, sustainability and quality in this sector.
Guillermo Sotorrío Ortega, Alfonso Cobo Escamilla, José A. Tenorio Ríos   +2 more
doaj   +1 more source

Enhancing graduate employability in hospitality, leisure, sport and tourism [PDF]

This paper is work-in-progress. The purpose of the paper is to describe the aims, context and methodology of a recently approved Fund for the Development of Teaching and Learning (FDTL) Phase 5 project. The aim of the project is to develop, implement and
Maher, Angela, Nield, Kevin
core  

Ontology Building of Manufacturing Quality Knowledge for Design Decision Support [PDF]

, 2010
This work was funded by National Natural Science Foundation of China (No: 70472066, 70771091), the project of Bureau of Science, Technology and Industry for National Defence, China (No. Z142008A001), the NPU Foundation for Humanities, Social Science, and
EYNARD, Benoit, MATTA, Nada, ROUCOULES, Lionel, TONG, Shurong, WANG, Keqin   +4 more
core   +3 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Organization of project training in an institution of higher education (on the example of Kemerovo State University)

Развитие образования
The requirements of federal state educational standards, professional standards and the labor market contribute to the introduction of project-based learning into the educational process of the university.
Olga Y. Glukhova, Alexander M. Gudov, Svetlana M. Sirik   +2 more
doaj   +1 more source

THE USING OF DIGITAL TOOLS IN THE PROJECT ACTIVITIES OF STUDENTS OF PEDAGOGICAL SPECIALTIES OF HIGHER EDUCATION INSTITUTIONS

Інформаційні технології і засоби навчання
The article substantiates the importance of projects for forming future teachersʼ readiness to work in the conditions of the «New Ukrainian School» reform, particularly the organization of project-based training.
Liudmyla Nezhyva, Svitlana Palamar, Nataliia Semenii   +2 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source