Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Sustainable Use of Natural Resources In Construction Works: a Case Study of Social Housing. [PDF]
, 2017 Optimizing the use of resources in the building process is a current problem and is also highly regarded in the latest European legislation. The problem can be tackled by minimizing waste production, promoting waste recovery and transforming waste into ...
Paparella, Rossana
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Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
A proposal for a course of Operations Management for the Degree in Electronics and Automatic
WPOM : Working Papers on Operations Management, 2017 At this work a methodology is proposed for a course of the discipline of Operations Management with a focus on active methodologies in the degree of Electronics and Automatic.
Pilar I. Vidal-Carreras +2 more
doaj +1 more source
The Identity Project: in-depth case studies of Identity Management - UCL institutional audit. Final report [PDF]
, 2008 This report presents the results of an audit of identity management practices at UCL, as part of Work Package 2 of The Identity Project (http://www.identity-project.info), a study funded under the JISC e-infrastructure programme, to address the current ...
Stone, M.
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Software Development Projects as a Way for Multidisciplinary Soft and Future Skills Education
Education SciencesThe modern job market demands soft and future skills from both technical and non-technical professionals. It is often challenging to teach these competencies in a traditional academic setting.
Krzysztof Podlaski +12 more
doaj +1 more source
In Search of the Regional Diversification of Latin: Some Methodological Considerations in Employing the Inscriptional Evidence. [PDF]
, 2012 The aim of the project entitled “Computerized Historical Linguistic Database of Latin Inscriptions of the Imperial Age” (http://lldb.elte.hu) is to develop and digitally publish a fundamental computerized historical linguistic database that incorporates
Adamik, Béla
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Methodology of project work: a new relationship between social skills and schooling skills [PDF]
, 2011 O trabalho de projeto é uma metodologia investigativa centrada na resolução de problemas reais e pertinentes, que permite criar uma nova relação entre a prática e a teoria, entre os saberes escolares e os saberes sociais. O tema, considerado oportuno e
Mateus, Maria do Nascimento Esteves
core +1 more source