Results 121 to 130 of about 2,282,257 (312)

Projection Problem [PDF]

, 2006
The property of presuppositions to be sometimes preserved through embeddings, albeit often in a weakened form, is called projection. The projection problem consists in formulating the conditions under which the presuppositions of an embedded clause (a) are kept as presuppositions of the superordinate structure, or (b) remain as an invited inference ...
openaire   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

How psychoanalyst works

Консультативная психология и психотерапия, 2010
The article provides a detailed course of long-term psychoanalytic therapy, with spe-cial attention to the detailes of the analyst's state and settings.
Rossokhin A.
doaj  

Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain [PDF]

, 2019
Johan Winnubst, Erhan Bas, Tiago Ferreira, Zhuhao Wu, Michael N. Economo, Patrick Edson, Benjamin Arthur, Christopher M. Bruns, Konrad Rokicki, David Schauder, Donald J. Olbris, Sean D. Murphy, David Ackerman, Cameron Arshadi, Perry Baldwin, Regina Blake, Ahmad Elsayed, Mashtura Hasan, Daniel Ramirez, Bruno Dos Santos, Monet Weldon, Amina Zafar, Joshua T. Dudman, Charles R. Gerfen, Adam W. Hantman, Wyatt Korff, Scott M. Sternson, Nelson Spruston, Karel Svoboda, Jayaram Chandrashekar   +29 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Temporal trends of particulate matter pollution and its health burden, 1990–2021, with projections to 2036: a systematic analysis for the global burden of disease study 2021

Frontiers in Public Health
BackgroundParticulate matter pollution (PM2.5) is a leading global health risk factor. We analyzed the spatiotemporal trends of diseases attributable to PM2.5 at global, regional, and national levels from 1990 to 2021.MethodsUsing data from the Global ...
Tao Fang, Tao Fang, Tao Fang, Yanbo Di, Yanbo Di, Yang Xu, Na Shen, Haojun Fan, Shike Hou, Shike Hou, Xiaoxue Li, Xiaoxue Li, Xiaoxue Li   +12 more
doaj   +1 more source

Spin projection and spin current density within relativistic electronic-transport calculations [PDF]

, 2010
S. Lowitzer, D. Ködderitzsch, H. Ebert
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Impact of extreme weather events on water resources and agriculture in Morocco

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2019
If Morocco is a country with low emissions of greenhouse gases, it remains vulnerable to the impact of climate change due to its geographical position and its dependence on climate-sensitive sectors such as agriculture.
Mohamed AOUBOUAZZA, Rachid RAJEL, Rachid ESSAFI   +2 more
doaj  

Comparison of affine-projection adaptive filter vs LMS speech enhancement systems [PDF]

, 2021
Rubén Hernández, Julio C. Sosa, V. H. García   +2 more
openalex   +1 more source