Results 51 to 60 of about 615,778 (249)

Projecting real world into CrowdIntell network: a methodology [PDF]

International Journal of Crowd Science, 2019
Purpose – The purpose of this paper is to build cyber-physical-psychological ternary fusion crowd intelligence network and realize comprehensive, real, correct and synchronous projection in cyber–physical–psychological ternary fusion system.
Shipeng Wang, Lizhen Cui, Lei Liu, Xudong Lu, Qingzhong Li   +4 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

“Here, I am More than Just Symptoms Combined”: Mental Health Services from the Perspective of Community Rehabilitation Groups

Journal of Patient Experience
In response to the rise in mental disorders, psychosocial and community approaches have been proposed, complementing traditional clinical services.
Felipe Agudelo Hernández PhD, MD, Daniela Rojas Loaiza MD, Eduardo Marulanda MD   +2 more
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Pancreatic cancer mortality trends attributable to high fasting blood sugar over the period 1990–2019 and projections up to 2040

Frontiers in Endocrinology
BackgroundPancreatic cancer (PC) is a prevalent malignancy within the digestive system, with diabetes recognized as one of its well-established risk factors.MethodsData on PC mortality attributed to high fasting blood sugar were retrieved from the Global
Yongguang Wei, Yongguang Wei, Yongguang Wei, Zedong Qin, Xiwen Liao, Xiwen Liao, Xiwen Liao, Xin Zhou, Xin Zhou, Xin Zhou, Huasheng Huang, Huasheng Huang, Huasheng Huang, Chenlu Lan, Chenlu Lan, Chenlu Lan, Wei Qin, Wei Qin, Wei Qin, Guangzhi Zhu, Guangzhi Zhu, Guangzhi Zhu, Hao Su, Hao Su, Hao Su, Tao Peng, Tao Peng, Tao Peng   +27 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Los embriones congelados frente al derecho sucesorio

Vergentis. Revista de Investigación de la Cátedra Internacional Conjunta Inocencio III, 2020
The question arises as to whether cryopreserved embryos are or can be heirs. Its situation incites more and more uncertainty and generates more conflicts of a juridical nature: filiatorial, inbreeding, identity, registration, succession, still unresolved.
Susana Isabel Estrada
doaj