Results 51 to 60 of about 531,090 (265)
Journal of Cheminformatics, 2019 Abstract The chemfp project has had four main goals: (1) promote the FPS format as a text-based exchange format for dense binary cheminformatics fingerprints, (2) develop a high-performance implementation of the BitBound algorithm that could be used as an effective baseline to benchmark new similarity search implementations, (3 ...
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Attachment style dimensions are associated with neural activation during projection of mental states
Frontiers in Human Neuroscience, 2022 The aim of the present study was to investigate the association between attachment dimensions and neural correlates in response to the Rorschach inkblots.
Carlo Lai +7 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Cogent Social SciencesThis article investigates the impact of information and communication technology (ICT) adoption and use on knowledge acquisition, organizational performance, and corporate entrepreneurship among tourism SMEs in Cali, Valle del Cauca (Colombia).
Jose Fabian Rios Obando +1 more
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New Estimates of Numerical Values Related to a Simplex
Моделирование и анализ информационных систем, 2017 Let \(n\in {\mathbb N}\) and \(Q_n=[0,1]^n\). For a nondegenerate simplex \(S\subset {\mathbb R}^n\), by \(\sigma S\) we denote the homothetic copy of~\(S\) with center of homothety in the center of gravity of \(S\) and ratio of~homothety \(\sigma\). By
Mikhail V. Nevskii, Alexey Yu. Ukhalov
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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From organising as projects to projects as organisations
International Journal of Project Management, 2008 Nowadays, projects and project management can be found in virtually all organisations. Accordingly, preventing project failure has become increasingly critical. In light of this, attempts have been made to redefine the conceptual bases of project management and to define new avenues for research, development of the field, and practical application.
Molloy, E, van Donk, D
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