Results 71 to 80 of about 145,936 (263)

Profile of the SCOAP3 project

open access: yes, 2007
Glennda Chui, Free for All, <em> Symmetry </em> , October/November 2007.
openaire   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

渐开线塑料齿轮齿廓偏差影像法测量的不确定度和抽样检验统计特性

open access: yesJixie chuandong, 2012
Applying projection method,the involute plastic gear tooth profile deviation is measured.As plastic gear tooth profile is much influenced by mechanical stress and thermal stress in machining,thus causing more tooth profile strain,to reflect precisely the
郑卫, 许耀东
doaj  

Velocity Estimation of Moving Target Based on Two-dimensional Projection for LFM UWB Radar

open access: yesLeida xuebao, 2012
Two-Dimensional (2D) projection in temporal-Doppler plan is utilized to solve the effects of range-Doppler coupling and Doppler dispersion on radial velocity estimation for Linear Frequency Modulation (LFM) Ultra-WideBand (UWB) radar.
Yang Li-min   +3 more
doaj   +1 more source

Profile of the PLEIADI Project

open access: yes, 2005
Ugo Contino and three co-authors, PLEIADI, un portale per la letteratura scientifica &#34;Open Access&#34;, Bollettino del Cilea, 99 (2005) pp. 11-16. Self-archived December 22, 2005.
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Simplification of Electrode Profiles for Piezoelectric Modal Sensors by Controlling Gap-Phase Length

open access: yesMathematics
This paper presents a method to optimize and simplify the electrode profile of a piezoelectric modal sensor. At the same time that the electrode profile is optimized to maximize the charge, a null-polarity phase is introduced.
Marta Martín-Nieto   +3 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

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