Results 141 to 150 of about 426,008 (281)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
, 2013 Pursuit, Dan - Oral History Interview - CSWA ❧ Interviewed by John Milner on July 26, 1995. An interview with Dan Pursuit as he discusses reasons for entering social work; education in social work at Western Reserve University; probation officer; work ...
Pursuit, Dan, interviewee
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Robust linear discriminant procedures using projection pursuit methods.
, 1989 Two projection indices are proposed for the construction of robust 2-sample linear discriminant functions using projection pursuit methods. The first robust projection index robustifies the classical Fisher ratio of between-class variation to within ...
Chen, Zen-Yi
core +1 more source
Assessing cerebral autoregulation via oscillatory lower body negative pressure and projection pursuit regression. [PDF]
J Vis Exp, 2014 Taylor JA, Tan CO, Hamner JW.
europepmc +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Augmented kurtosis-based projection pursuit: a novel, advanced machine learning approach for multi-omics data analysis and integration. [PDF]
Nucleic Acids ResBong F +6 more
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Lifting the curse from high-dimensional data: automated projection pursuit clustering for a variety of biological data modalities. [PDF]
GigascienceSimpson C +17 more
europepmc +1 more source