Results 141 to 150 of about 10,982 (282)
The asymptotic tail behaviours of projection pursuit-type Kolmogorov statistics [PDF]
In this paper, we obtain bounds for the tail probabilities of limit variables of projection pursuit-type Kolmogorov statistics.Gaussian processes Kolmogorov statistic Projection pursuit Tail ...
Cheng, Ping, Zhu, Li-Xing
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A Characterization of Principal Components for Projection Pursuit [PDF]
, 1999 Principal Component Analysis is a technique often found to be useful for identifying structure in multivariate data. Although it has various characterizations (Rao 1964), the most familiar is as a variance-maximizing projection.
Richard J. Bolton, Wojtek J. Krzanowski
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Projection Pursuit via Multivariate Histograms [PDF]
, 1985 The problem of finding the most interesting low-dimensional subspaces of a multidimensional data set has usually been formulated as a search for the maximum over all projection subspaces of a measure of information.
Terrell, George R.
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
工程科学与技术, 2019 Dry gas seal is one of the important sealing methods in shaft seal, especially for the devices with high sealing reliability requirements. Due to the designed relationship between the sealing gas film and the seal rings, the vibration of the floating ...
Yun LIU +3 more
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source