Results 121 to 130 of about 10,982 (282)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Water Safety Evaluation in the Regions of Wenchuan Earthquake Landslide Lake
工程科学与技术, 2010 :The issue of water safety has become the national strategic safety issue. Water safety problems in the regions of a number of landslide lakes formed by an earthquake will cause significant harm.
Tang Gui-juan
doaj
Ecological environment quality evaluation of Zhangjiamao mining area based on DBO–PPC model
Meitan xuebaoMining will destroy and occupy a large amount of land resources and cause lasting negative impact on ecological environment, so it is urgent to evaluate the change of ecological environment quality in mining area.
Ying LIU +10 more
doaj +1 more source
Robust linear discriminant procedures using projection pursuit methods. [PDF]
, 1989 Two projection indices are proposed for the construction of robust 2-sample linear discriminant functions using projection pursuit methods. The first robust projection index robustifies the classical Fisher ratio of between-class variation to within ...
Chen, Zen-Yi
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
O dvou flexibilních metodách pro dvourozměrnou regresní analýzu [PDF]
ACC Journal, 2012 Práce je věnována neparametrickému statistickému modelování dvourozměrných ploch na základě pozorovaných dat, tj. dvourozměrně regresni analýze. Model je konstruován jako kombinace jednoduchých bázových funkcí, jako jsou spliny, gaussiány apod. Nevýhodou
Petr Volf
doaj
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Projection pursuit optimisation using a genetic algorithm [PDF]
, 1999 This paper describes the application of a genetic algorithm to the optimisation of a data projection method known as projection pursuit. Exploratory projection pursuit, named by Friedman and Tukey (1974) is a statistical method for viewing low (typically
Andrew Hunter (17160442) +1 more
core +2 more sources