Results 101 to 110 of about 10,982 (282)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Two Dimensional Projection Pursuit Applied to Gaussian Mixture Model Fitting [PDF]

Journal of Systemics, Cybernetics and Informatics, 2003
In this paper we seek a Gaussian mixture model (GMM) of an n-variate probability density function. Usually the parameters of GMMs are determined by a maximum likelihood (ML) criterion. A practical deficiency of ML fitting of GMMs is poor performance when
Natella Likhterov, Mayer Aladjem
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Projection Pursuit Dynamic Cluster Model and Its Application in Groundwater Classification

工程科学与技术, 2006
:A projection pursuit dynamic cluster (PPDC) model is proposed, which combines projection pursuit principle with dynamic cluster rule. Firstly, multifactor cluster problem is converted into single-factor cluster problem according to linear projection ...
doaj  

Non-hypothetical projection pursuit regression for the prediction of hydration heat of Portland-cement-based cementitious system. [PDF]

Heliyon, 2023
Qin C, Gong J, Xie G, He J, Liu L, Yang H, Deng C.   +6 more
europepmc   +1 more source

Optimization in a Simulation Setting: Use of Function Approximation in Debt Strategy Analysis [PDF]

The stochastic simulation model suggested by Bolder (2003) for the analysis of the federal government's debt-management strategy provides a wide variety of useful information.
Tiago Rubin, David Jamieson Bolder
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Determining food tourism consumption of wild mushrooms in Yunnan Provence, China: A projection-pursuit approach. [PDF]

Heliyon, 2023
Lin J, Zhang B, Feng J, Yi Z, Zhang H, Luo M, Zhong Z, Zhao F.   +7 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Average relative flow of single-wing labyrinth drip irrigation tape based on projection pursuit regression. [PDF]

Sci Rep, 2022
Tao H, Tao J, Li Q, Aihemaiti M, Jiang Y, Yang W, Wei J.   +6 more
europepmc   +1 more source