Results 91 to 100 of about 426,008 (281)
Robust sparse principal component analysis. [PDF]
A method for principal component analysis is proposed that is sparse and robust at the same time. The sparsity delivers principal components that have loadings on a small number of variables, making them easier to interpret.
Croux, Christophe +2 more
core
High dimensional feature reduction via projection pursuit [PDF]
, 1996 The recent development of more sophisticated sensors for remote sensing systems enables the measurement of radiation in many more spectral intervals than previously possible.
Jimenez, Luis Orlando
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Two Dimensional Projection Pursuit Applied to Gaussian Mixture Model Fitting [PDF]
Journal of Systemics, Cybernetics and Informatics, 2003 In this paper we seek a Gaussian mixture model (GMM) of an n-variate probability density function. Usually the parameters of GMMs are determined by a maximum likelihood (ML) criterion. A practical deficiency of ML fitting of GMMs is poor performance when
Natella Likhterov, Mayer Aladjem
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Projection Pursuit Dynamic Cluster Model and Its Application in Groundwater Classification
工程科学与技术, 2006 :A projection pursuit dynamic cluster (PPDC) model is proposed, which combines projection pursuit principle with dynamic cluster rule. Firstly, multifactor cluster problem is converted into single-factor cluster problem according to linear projection ...
doaj
Non-hypothetical projection pursuit regression for the prediction of hydration heat of Portland-cement-based cementitious system. [PDF]
Heliyon, 2023 Qin C +6 more
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Classifiability-based optimal discriminatory projection pursuit [PDF]
, 2008 Linear Discriminant Analysis (LDA) might be the most widely used linear feature extraction method in pattern recognition. Based on the analysis on the several limitations of traditional LDA, this paper makes an effort to propose a new computational ...
Wen Gao +7 more
core +1 more source