Results 71 to 80 of about 426,008 (281)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Projection Pursuit for Exploratory Supervised Classification [PDF]

In high-dimensional data, one often seeks a few interesting low-dimensional projections that reveal important features of the data. Projection pursuit is a procedure for searching high-dimensional data for interesting low-dimensional projections via the ...
Thomas Lumley, Dianne Cook, Sigbert Klinke, Eun-Kyung Lee   +3 more
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Data-driven identification of swell potential of clayey soils for engineering surveying using genetic projection pursuit

Frontiers in Earth Science
Accurately classifying swell potential grades of clayey soils remains a significant challenge in geotechnical engineering, primarily due to the complex interplay of multiple factors that govern swelling-shrinkage behavior.
Kangming Lou, Kangming Lou, Kangming Lou, Zhu Liang, Zhu Liang, Zhu Liang, Jianhui Tan, Jianhui Tan, Jianhui Tan, Jiaming Huang, Jiaming Huang, Jiaming Huang, Zhiyuan Zhou, Zhiyuan Zhou, Zhiyuan Zhou   +14 more
doaj   +1 more source

Goodness-of-Fit Tests For Elliptical and Independent Copulas through Projection Pursuit

Algorithms, 2011
Two goodness-of-fit tests for copulas are being investigated. The first one deals with the case of elliptical copulas and the second one deals with independent copulas.
Jacques Touboul
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Toward the Health Measure for Open Source Software Ecosystem Via Projection Pursuit and Real-Coded Accelerated Genetic

IEEE Access, 2019
The benign development of Open-source Software Ecosystem (or OSSE) helps to fuse the wisdom of the community. It can facilitate the development and solve the urgent application needs of large-scale complex software systems.
Lei Wang, Jing Wan, Xinshu Gao
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Projection pursuit for bank data

, 2022
Projection pursuit for bank data.The world, continental and national crises faced by the financial system since 2008 have been addressed by both national and international authorities by favoring financial stability with respect to economic efficiency ...
Alessandro Berti, Cinzia Franceschini, Nicola Loperfido   +2 more
core   +1 more source