Results 81 to 90 of about 426,008 (281)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Projection-pursuit-based method for blind separation of nonnegative sources
, 2013 This paper presents a projection pursuit (PP) based method for blind separation of nonnegative sources. First, the available observation matrix is mapped to construct a new mixing model, in which the inaccessible source matrix is normalized to be column ...
Y Rong (13483264) +3 more
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Robust canonical correlations: a comparative study. [PDF]
Several approaches for robust canonical correlation analysis will be presented and discussed. A first method is based on the definition of canonical correlation analysis as looking for linear combinations of two sets of variables having maximal (robust ...
Croux, Christophe +3 more
core
Application of Projection Pursuit Dynamic Cluster Model in Water Resources Assessment
工程科学与技术, 2008 :A projection pursuit dynamic cluster model is developed, and it is used in water resources assessment for the first time.The projection pursuit dynamic cluster model combines projection pursuit principle with dynamic cluster method.Firstly,multifactor ...
doaj
Determining the number of clusters using nonparametric statistics
Lietuvos Matematikos Rinkinys, 1997 A Gaussian mixture model is investigated in this paper. A method for estimation of unknown number of clusters in the case of equal covariance matrices is discribed. This method is based on the use of projection pursuit.
Darius Šimoliūnas
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Multiple outlier detection in multivariate data using projection pursuit techniques
, 2000 Using projection pursuit techniques, in this paper we propose a procedure to detect multiple outliers in multivariate data. The basic idea behind this procedure is to project the multivariate data to univariate observations and then to apply an ...
Fung, WK +8 more
core +1 more source
Data processing method for telecom data based on projection pursuit
Dianxin kexue, 2016 In the big data era, the data which operator can collect and process is quickly growing. At the same time, due to the high dimension of the data, it is very difficult to extract and process information from them.
Jinming ZHAO
doaj +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source