Results 121 to 130 of about 2,066,066 (332)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Optimal Policy Projections [PDF]

We outline a method to provide advice on optimal monetary policy while taking policymakers’ judgment into account. The method constructs optimal policy projections (OPPs) by extracting the judgment terms that allow a model, such as the Federal Reserve ...
Svensson, Lars O, Tetlow, Robert J
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

THE RESEARCH OF USING «THE COST RECOVERY» METHOD IN THE COST MANAGEMENT

Вестник университета, 2019
The article is about «Cost recovery» method. It is considered how the method can be used in the various types of tasks (the account, planning, forecasting, rationing, optimization, etc.).
Y. Vorontsova, I. Barakhanova
doaj  

Identification of a Hippocampus‐to‐Zona Incerta Projection involved in Motor Learning

Advanced Science
Motor learning (ML), which plays a fundamental role in growth and physical rehabilitation, involves different stages of learning and memory processes through different brain regions.
Zhuo‐Hang Zhang, Bo Wang, Yan Peng, Ya‐Wei Xu, Chang‐Hong Li, Ya‐Lei Ning, Yan Zhao, Fa‐Bo Shan, Bo Zhang, Nan Yang, Jing Zhang, Xing Chen, Ren‐Ping Xiong, Yuan‐Guo Zhou, Ping Li   +14 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Causes of Increased Compound Temperature and Precipitation Extreme Events in the Arid Region of Northwest China from 1961 to 2100

Remote Sensing
Compound extreme events pose more grave threats to human health, the natural environment, and socioeconomic systems than do individual extreme events. However, the drivers and spatiotemporal change characteristics of compound extreme events under climate
Huihui Niu, Weijun Sun, Baojuan Huai, Yuzhe Wang, Rensheng Chen, Chuntan Han, Yingshan Wang, Jiaying Zhou, Lei Wang   +8 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Projection of populations by level of educational attainment, age, and sex for 120 countries for 2005-2050

Demographic Research, 2010
Using demographic multi-state, cohort-component methods, we produce projections for 120 countries (covering 93Š of the world population in 2005) by five-year age groups, sex, and four levels of educational attainment for the years 2005-2050. Taking
Samir KC, Bilal Barakat, Anne Goujon, Vegard Skirbekk, Wolfgang Lutz   +4 more
doaj  

International Agricultural Baseline Projections to 2007 [PDF]

This report provides baseline projections for international supply, demand, and trade for major agricultural commodities to 2007. It is a companion report to USDA Agricultural Baseline Projections, providing the foreign country details supporting those ...
Landes, Rip, Wainio, John, Westcott, Paul C.   +2 more
core   +1 more source