Results 101 to 110 of about 1,461,323 (289)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
THE RESEARCH OF USING «THE COST RECOVERY» METHOD IN THE COST MANAGEMENT
Вестник университета, 2019 The article is about «Cost recovery» method. It is considered how the method can be used in the various types of tasks (the account, planning, forecasting, rationing, optimization, etc.).
Y. Vorontsova, I. Barakhanova
doaj
Identification of a Hippocampus‐to‐Zona Incerta Projection involved in Motor Learning
Advanced ScienceMotor learning (ML), which plays a fundamental role in growth and physical rehabilitation, involves different stages of learning and memory processes through different brain regions.
Zhuo‐Hang Zhang +14 more
doaj +1 more source
A non-injective version of Wigner's theorem
, 2018 Let $H$ be a complex Hilbert space and let ${\mathcal F}_{s}(H)$ be the real vector space formed by all self-adjoint finite rank operators on $H$. We prove the following non-injective version of Wigner's theorem: every linear operator on ${\mathcal F}_{s}
Pankov, Mark, Plevnik, Lucijan
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Remote SensingCompound extreme events pose more grave threats to human health, the natural environment, and socioeconomic systems than do individual extreme events. However, the drivers and spatiotemporal change characteristics of compound extreme events under climate
Huihui Niu +8 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Demographic Research, 2010 Using demographic multi-state, cohort-component methods, we produce projections for 120 countries (covering 93Š of the world population in 2005) by five-year age groups, sex, and four levels of educational attainment for the years 2005-2050. Taking
Samir KC +4 more
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