Results 91 to 100 of about 353,264 (267)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

THE RESEARCH OF USING «THE COST RECOVERY» METHOD IN THE COST MANAGEMENT

Вестник университета, 2019
The article is about «Cost recovery» method. It is considered how the method can be used in the various types of tasks (the account, planning, forecasting, rationing, optimization, etc.).
Y. Vorontsova, I. Barakhanova
doaj  

Identification of a Hippocampus‐to‐Zona Incerta Projection involved in Motor Learning

Advanced Science
Motor learning (ML), which plays a fundamental role in growth and physical rehabilitation, involves different stages of learning and memory processes through different brain regions.
Zhuo‐Hang Zhang, Bo Wang, Yan Peng, Ya‐Wei Xu, Chang‐Hong Li, Ya‐Lei Ning, Yan Zhao, Fa‐Bo Shan, Bo Zhang, Nan Yang, Jing Zhang, Xing Chen, Ren‐Ping Xiong, Yuan‐Guo Zhou, Ping Li   +14 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Causes of Increased Compound Temperature and Precipitation Extreme Events in the Arid Region of Northwest China from 1961 to 2100

Remote Sensing
Compound extreme events pose more grave threats to human health, the natural environment, and socioeconomic systems than do individual extreme events. However, the drivers and spatiotemporal change characteristics of compound extreme events under climate
Huihui Niu, Weijun Sun, Baojuan Huai, Yuzhe Wang, Rensheng Chen, Chuntan Han, Yingshan Wang, Jiaying Zhou, Lei Wang   +8 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Projection of populations by level of educational attainment, age, and sex for 120 countries for 2005-2050

Demographic Research, 2010
Using demographic multi-state, cohort-component methods, we produce projections for 120 countries (covering 93Š of the world population in 2005) by five-year age groups, sex, and four levels of educational attainment for the years 2005-2050. Taking
Samir KC, Bilal Barakat, Anne Goujon, Vegard Skirbekk, Wolfgang Lutz   +4 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

TEACHING DESCRIPTIVE GEOMETRY – CONSTRUCTING AND DEVELOPING THE SURFACES OF SOLIDS

Journal of Industrial Design and Engineering Graphics, 2019
The paper presents applications developed for teaching descriptive geometry – representation of solids and development of the surface of the solids. The purpose of the applications presented is to enable the development and improvement of the spatial ...
Ramona Clinciu
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source