Results 81 to 90 of about 1,461,323 (289)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
, 1998 Let $X\subset P^N$ be an n-dimensional connected projective submanifold of projective space. Let $p : P^N\to P^{N-q-1}$ denote the projection from a linear $P^q\subset P^N$. Assuming that $X\not\subset P^q$ we have the induced rational mapping $\psi:=p_X:
Beltrametti, Mauro C. +3 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The unusual microtubule polarity in teleost retinal pigment epithelial cells. [PDF]
, 1988 In cells of the teleost retinal pigment epithelium (RPE), melanin granules disperse into the RPE cells long apical projections in response to light onset, and aggregate toward the base of the RPE cell in response to dark onset.
BURNSIDE, Beth, Troutt, L
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Journal of ImagingConventional radiography is widely used for postmortem foetal imaging, but its role in diagnosing congenital anomalies is debated. This study aimed to assess the effectiveness of X-rays in detecting skeletal abnormalities and guiding genetic analysis and
Benedetta Rossini +5 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Nature and Science of Sleep, 2020 Ya-Nan Zhao,1,* Yu-Dong Yan,1,* Chen-Yao Wang,1 Wei-Min Qu,1 Thomas C Jhou,2 Zhi-Li Huang,1 Su-Rong Yang1 1Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of China; 2Department of ...
Zhao YN +6 more
doaj
Principal angles and approximation for quaternionic projections
, 2013 We extend Jordan's notion of principal angles to work for two subspaces of quaternionic space, and so have a method to analyze two orthogonal projections in M_n(A) for A the real, complex or quaternionic field (or skew field).
Loring, Terry A.
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