Results 121 to 130 of about 1,329,018 (301)
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Flexibility and rigidity of three-dimensional convex projective structures [PDF]
, 2013 textThis thesis investigates various rigidity and flexibility phenomena of convex projective structures on hyperbolic manifolds, particularly in dimension 3.
Ballas, Samuel Aaron +1 more
core
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Characteristic classes and projective modules [PDF]
This thesis is in 4 separate parts, of which Chapters 1 and 2. form the first part, and Chapters 3,4,5 are the remaining parts. The thesis is concerned with characteristic classes, which can be viewed as obstructions to stable triviality. In C:lapter 1
Thomas, A. D.
core
Constant coefficient and intersection complex $L$-classes of projective varieties [PDF]
For a projective variety $X$ we have the intersection complex $L$-class defined by using the self-duality of the intersection complex and also the constant coefficient $L$-class which is the specialization at $y=1$ of the Hirzebruch characteristic class ...
Pallarés, Irma +2 more
core +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
projective-splitting/just-continuity: Version 1.0
, 2019 <p>Version of August 26, 2019</p> <p>Python code to reproduce computational results in "Projective Splitting with Forward Steps only Requires Continuity", Patrick R. Johnstone and Jonathan Eckstein, https://arxiv.org/pdf/1809.
Jonathan Eckstein +1 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source