Results 81 to 90 of about 2,365 (306)

Holonomy and Projective Equivalence in 4-Dimensional Lorentz Manifolds

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2009
A study is made of 4-dimensional Lorentz manifolds which are projectively related, that is, whose Levi-Civita connections give rise to the same (unparameterised) geodesics. A brief review of some relevant recent work is provided and a list of new results
David P. Lonie, Graham S. Hall
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Logarithmic connections with vanishing p-curvature [PDF]

open access: yes, 2009
We examine logarithmic connections with vanishing p-curvature on smooth curves by studying their kernels, describing them in terms of formal local decomposition.
Osserman, Brian
core   +1 more source

Parallel transports in the connections of three types for cocongruence K(n-m)m

open access: yesДифференциальная геометрия многообразий фигур
We continue to study the cocongruence of -dimensional planes us­ing the Cartan — Laptev method. In an -dimensional projective space , the cocongruence of -dimensional planes can be given by the following equations .
Belova O. O.
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

On split quasi-hereditary covers and Ringel duality

open access: yesForum of Mathematics, Sigma
In this paper, we develop two new homological invariants called relative dominant dimension with respect to a module and relative codominant dimension with respect to a module.
Tiago Cruz
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Holomorphic projective connections on surfaces and osculating spaces [PDF]

open access: yes
We study complex analytic projective connections on surfaces in projective n-spaces in terms of the "second" neighborhood of the surface in the ambient space, and in terms of the osculating behavior of the integral curves.
Wone, Oumar
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Connections for weighted projective lines [PDF]

open access: yes, 2011
We introduce a notion of a connection on a coherent sheaf on a weighted projective line (in the sense of Geigle and Lenzing). Using a theorem of Hübner and Lenzing we show, under a mild hypothesis, that if one considers coherent sheaves equipped with ...
Crawley-Boevey, William
core   +1 more source

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