Results 81 to 90 of about 2,365 (306)
Holonomy and Projective Equivalence in 4-Dimensional Lorentz Manifolds
A study is made of 4-dimensional Lorentz manifolds which are projectively related, that is, whose Levi-Civita connections give rise to the same (unparameterised) geodesics. A brief review of some relevant recent work is provided and a list of new results
David P. Lonie, Graham S. Hall
doaj +1 more source
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Logarithmic connections with vanishing p-curvature [PDF]
We examine logarithmic connections with vanishing p-curvature on smooth curves by studying their kernels, describing them in terms of formal local decomposition.
Osserman, Brian
core +1 more source
Parallel transports in the connections of three types for cocongruence K(n-m)m
We continue to study the cocongruence of -dimensional planes using the Cartan — Laptev method. In an -dimensional projective space , the cocongruence of -dimensional planes can be given by the following equations .
Belova O. O.
doaj +1 more source
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
On split quasi-hereditary covers and Ringel duality
In this paper, we develop two new homological invariants called relative dominant dimension with respect to a module and relative codominant dimension with respect to a module.
Tiago Cruz
doaj +1 more source
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Holomorphic projective connections on surfaces and osculating spaces [PDF]
We study complex analytic projective connections on surfaces in projective n-spaces in terms of the "second" neighborhood of the surface in the ambient space, and in terms of the osculating behavior of the integral curves.
Wone, Oumar
core +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Connections for weighted projective lines [PDF]
We introduce a notion of a connection on a coherent sheaf on a weighted projective line (in the sense of Geigle and Lenzing). Using a theorem of Hübner and Lenzing we show, under a mild hypothesis, that if one considers coherent sheaves equipped with ...
Crawley-Boevey, William
core +1 more source

