Results 51 to 60 of about 1,352,108 (296)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Vegetation recovery in fire-damaged forests: a case study at the southern boundary of the taiga zone

Metsanduslikud Uurimused, 2016
Wildfire is regarded as important environmental factor determining the vegetation of the Earth. We analyzed 11 plots at different types of forest affected by fire at the southern boundary of the taiga zone.
Khapugin Anatoliy A., Vargot Elena V., Chugunov Gennadiy G.   +2 more
doaj   +1 more source

On the validation of spatial statistical vegetation models

BIO Web of Conferences, 2019
The features of coefficients of determination and coefficients of leave-one-out method for spatial vegetation model and spatial models of squared deviations are discussed. The properties of models are illustrated in key area for spatial model of Cladonia
Makhatkov Igor
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Enlargement of Symmetry Groups in Physics: A Practitioner’s Guide

Universe
Wigner’s classification has led to the insight that projective unitary representations play a prominent role in quantum mechanics. The physics literature often states that the theory of projective unitary representations can be reduced to the theory of ...
Lehel Csillag, Julio Marny Hoff da Silva, Tudor Pătuleanu   +2 more
doaj   +1 more source

Ecological assessment of spatial dynamics of forest ecosystem indicators in megacity conditions [PDF]

E3S Web of Conferences
The condition and resilience of urban forest ecosystems are subject to increasing anthropogenic pressure associated with the growth of megacities. This study presents the results of long-term ecological monitoring (2018–2022) conducted on the territory ...
Iliushkova Elena M., Tikhonova Maria V., Zhigaleva Yaroslava S., Latysheva Olga S.   +3 more
doaj   +1 more source

Update to Cover Oregon business plan, 2014-2015 [PDF]

, 2014
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF cover (viewed on August 20, 2015).Mode of ...

core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source