Results 41 to 50 of about 46,964 (266)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

About Structure of Graph Obstructions for Klein Surface with 9 Vertices

Кібернетика та комп'ютерні технології, 2020
The structure of the 9 vertex obstructive graphs for the nonorientable surface of the genus 2 is established by the method of (-transformations of the graphs.
V.I. Petrenjuk, D.A. Petrenjuk
doaj   +1 more source

Existence of covers with fixed ramification in positive characteristic

, 2012
We discuss two elementary constructions for covers with fixed ramification in positive characteristic. As an application, we compute the number of certain classes of covers between projective lines branched at 4 points and obtain information on the ...
IRENE I. BOUW, LEONARDO ZAPPONI, Mochizuki S.   +2 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Fields of geometric objects associated with compiled hyperplaneH H(Λ,L) -distribution in affine space

Дифференциальная геометрия многообразий фигур, 2020
A compiled hyperplane distribution is considered in an n-dimensional projective space . We will briefly call it a -distribution. Note that the plane L(A) is the distribution characteristic obtained by displacement in the center belonging to the L ...
Yu. I. Popov
doaj   +1 more source

Pencils and Infinite Dihedral covers of P^2

, 2004
In this work we study the connection between the existence of finite dihedral covers of the projective plane ramified along an algebraic curve C, infinite dihedral covers, and pencils of curves containing C.Comment: 1o ...
Bartolo, E. Artal, Cogolludo, Jose Ignacio, Tokunaga, Hiro-o   +2 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

An Arabic Grammar Auditor Based on Dependency Grammar

Advances in Human-Computer Interaction, 2020
The Arabic language has many complex grammar rules that may seem complicated to the average user or learner. Automatic grammar checking systems can improve the quality of the text, reduce the costs of the proofreading process, and play a role in grammar ...
Ameerah Alothman, AbdulMalik Alsalman
doaj   +1 more source

On multigraded generalizations of Kirillov-Reshetikhin modules

, 2012
We study the category of Z^l-graded modules with finite-dimensional graded pieces for certain Z+^l-graded Lie algebras. We also consider certain Serre subcategories with finitely many isomorphism classes of simple objects.
A Khare, A Moura, A Moura, A Schilling, A Schilling, Adriano Moura, Angelo Bianchi, B Feigin, D Hernandez, E Neher, G Fourier, G Fourier, G Hatayama, G Hatayama, Ghislain Fourier, K Naoi, M Lau, P Batra, P Francesco Di, R Kodera, R Kodera, S Naito, V Chari, V Chari, V Chari, V Chari, V Chari, V Chari, V Chari, V Chari, V Chari, V Chari, Vyjayanthi Chari, W Nakai, W Nakai   +34 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source