Results 31 to 40 of about 646 (225)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Positive geometries and canonical forms
Journal of High Energy Physics, 2017 Recent years have seen a surprising connection between the physics of scattering amplitudes and a class of mathematical objects — the positive Grassmannian, positive loop Grassmannians, tree and loop Amplituhedra — which have been loosely referred to as “
Nima Arkani-Hamed +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Differentiable Manifolds and Geometric Structures
MathematicsThis editorial presents 26 research articles published in the Special Issue entitled Differentiable Manifolds and Geometric Structures of the MDPI Mathematics journal, which covers a wide range of topics particularly from the geometry of (pseudo ...
Adara M. Blaga
doaj +1 more source
Differential Geometry of Submanifolds of Projective Space [PDF]
, 2008 These are lecture notes on the rigidity of submanifolds of projective space "resembling" compact Hermitian symmetric spaces in their homogeneous embeddings. Recent results are surveyed, along with their classical predecessors. The notes include an introduction to moving frames in projective geometry, an exposition of the Hwang-Yamaguchi ridgidity ...
openaire +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Differential Invariants of Conformal and Projective Surfaces
Symmetry, Integrability and Geometry: Methods and Applications, 2007 We show that, for both the conformal and projective groups, all the differential invariants of a generic surface in three-dimensional space can be written as combinations of the invariant derivatives of a single differential invariant. The proof is based
Evelyne Hubert, Peter J. Olver
doaj
Integration-by-parts identities and differential equations for parametrised Feynman integrals
Journal of High Energy PhysicsIntegration-by-parts (IBP) identities and differential equations are the primary modern tools for the evaluation of high-order Feynman integrals. They are commonly derived and implemented in the momentum-space representation.
Daniele Artico, Lorenzo Magnea
doaj +1 more source
Metrics in Projective Differential Geometry: The Geometry of Solutions to the Metrizability Equation [PDF]
The Journal of Geometric Analysis, 2018 27 pages.
Keegan Flood, A. Rod Gover
openaire +3 more sources