Results 51 to 60 of about 188,835 (324)
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Projective and other locative PPs in Greek
Glossa, 2022 The distinction between projective and non-projective locative prepositions that has been proposed in the semantic literature (Zwarts & Winter 2000) is reflected in the syntax and morphology of Greek spatial expressions.
Athanasios Michail Ramadanidis
doaj +2 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Dynamics of real projective transformations
Applied General Topology, 2018 The dynamics of a projective transformation on a real projective space are studied in this paper. The two main aspects of these transformations that are studied here are the topological entropy and the zeta function.
Sharan Gopal, Srikanth Ravulapalli
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
A Dual of the Chow Transformation
Complex Manifolds, 2018 We define a dual of the Chow transformation of currents on the complex projective space. This transformation factorizes a left inverse of the Chow transformation and its composition with the Chow transformation is a right inverse of a linear diferential ...
Méo Michel
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Rigidity through a Projective Lens
Applied Sciences, 2021 In this paper, we offer an overview of a number of results on the static rigidity and infinitesimal rigidity of discrete structures which are embedded in projective geometric reasoning, representations, and transformations.
Anthony Nixon +2 more
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Accounts of Chemical Research, 2015 One of the simplest questions that can be asked about molecular diversity is how many organic molecules are possible in total? To answer this question, my research group has computationally enumerated all possible organic molecules up to a certain size to gain an unbiased insight into the entire chemical space. Our latest database, GDB-17, contains 166.
openaire +4 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source