Results 101 to 110 of about 12,961,695 (366)

Drilling techniques presently in use by the Geothermal Studies Project, U.S. Geological Survey [PDF]

, 1979
Thomas H. Moses, J.H. Sass
openalex   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Game-Based Technique for Studying Identity Change in Disturbed Communities

Qualitative Sociology Review
Studying social identity change in non-standard contexts is always challenging. This article presents a new research technique that allows researchers to obtain rich and ethical data even in adverse and fragile conditions.
Elisabeth Kovtiak
doaj   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

High school students’ perceptions of professional future: results of the application of the sentence completion method

Український соціум
The article focuses on the peculiarities of the professional self-determination of Ukrainian high school students in a risk society and a liquid modernity characterised by uncertainty, social instability and transformation in the field of education and ...
Bieliaieva V. O.
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

STUDY OF THE PERSONALITY OF A CHILD WITH MENTAL DEVELOPMENTAL DELAY USING THE HOUSE-TREE-PERSON PROJECTIVE TECHNIQUE

Russian Journal of Education and Psychology
Background. The article is dedicated to the use of projective techniques in the diagnosis of children with mental developmental delays. It highlights that initiating diagnostic assessments for these children is driven not only by challenges in mastering ...
Yulia T. Antonova, Ayyna I. Vinokurova, Diana I. Permyakov   +2 more
doaj   +1 more source

Fixed Points of Maps of a Nonaspherical Wedge

Fixed Point Theory and Applications, 2009
Let X be a finite polyhedron that has the homotopy type of the wedge of the projective plane and the circle. With the aid of techniques from combinatorial group theory, we obtain formulas for the Nielsen numbers of the selfmaps of X.
Seung Won Kim, Robert F. Brown, Adam Ericksen, Nirattaya Khamsemanan, Keith Merrill   +4 more
doaj   +1 more source

A course and project description for an undergraduate course in evaluation and measurement techniques for computer systems [PDF]

, 1976
Billy G. Claybrook
openalex   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source