Results 111 to 120 of about 10,029 (291)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

AN OPTIMIZED AGILE TECHNIQUE TO EFFECTIVELY IMPLEMENT AGILE METHODS IN PROJECT MANAGEMENT: A RESEARCH PROPOSITION

, 2018
Rosarito Sánchez‐Morcilio, Francisco Quiles-Torres, C Baham, R Hirschheim, A Calderon, V Kisekka, V Bhoola, D Mallik, I Bider, E Perjons, J Birkinshaw, E Conforto, F Salum, D Amaral, S Da Silva, L Magnanini De Almeida, E Crocetti, M Crowther, W Lim, R Dovleac, A Ionic, J Erickson, K Lyytinen, K Siau, N Garnett, D Jones, S Murray, T Gustavsson, V Henriques, M Tanner, M Hwang, M Hwang, J Windsor, A Pryor, P Kettunen, M Laanti, M Kim, Y Park, R Kotalwar, J Kisielnicki, A Misiak, S Kudaravalli, S Faraj, S Johnson, T Lechler, S Yang, M Makoto-Higuchi, D Noboru-Nakano, M Manole, M Avramescu, A Mihalache, M Mirzaei, V Mabin, S Nkukwana, N Terblanche, S Rajagopalan, S Mathew, N Ramasubbu, A Bharadwaj, G Tayi, N Repenning, D Kieffer, J Repenning, M Stoica, B Ghilic-Micu, M Mircea, C Uscatu, W Tsai, C Chen, C Chen, J Varajo, J Weber, D Frster, M Stbler, K Paetzold, T Wolfgang   +75 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The Implementation of Shape Poem Technique in Project-Based Learning in Teaching English Vocabulary at an Elementary School: A Pre-Experimental Research [PDF]

Ni Kadek Mentari, Ni Nyoman Padmadewi, Luh Putu Artini   +2 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Risk Analysis Techniques for ERP Projects based on Seasonal Uncertainty Events

, 2020
Paulo Mannini, Edmir Parada Vasques Prado, Alexandre Grotta, Leandro F. M. Rezende   +3 more
openalex   +1 more source

Book Review: The Prediction of Overt Behavior through the use of Projective Techniques [PDF]

, 1961
R. W. Payne
openalex   +1 more source

Rockburst Hazard Prediction in Underground Projects Using Two Intelligent Classification Techniques: A Comparative Study [PDF]

, 2021
Mahmood Ahmad, Jilei Hu, Marijana Hadzima-Nyarko, Feezan Ahmad, Xiaowei Tang, Zia Ur Rahman, Ahsan Nawaz, Muhammad Abrar   +7 more
openalex   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source