Results 111 to 120 of about 9,722 (294)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Silicon ingot casting - heat exchanger method multi-wire slicing - fixed abrasive slicing technique, Phase III. Silicon sheet growth development for the large area sheet task of the Low-Cost Solar Array Project. Quarterly progress report No. 2, January 1-March 31, 1979

, 1979
F. Schmid, C. P. Khattak
openalex   +2 more sources

Techniques for approaching the dual Ramsey property in the projective hierarchy [PDF]

, 2001
Lorenz Halbeısen, Benedikt Löwe
openalex   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Determination of the Relationships of Electrical Resistivity, Sound Velocity, and Density/Porosity of Sediment and Rock by Laboratory Techniques and Well Logs from Deep Sea Drilling Project Sites 415 and 416 off the Coast of Morocco

, 1980
R.E. Boyce
openalex   +1 more source

Elicitation techniques in a Dutch syntactic dialect atlas project [PDF]

, 2001
Leonie Cornips, Willy Jongenburger
openalex   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Silicon ingot casting: heat exchanger method (HEM). Multi-wire slicing: fixed abrasive slicing technique (FAST). Phase IV. Silicon sheet growth development for the large area sheet task of the low-cost solar array project. Quarterly progress report No. 3, July 1, 1980-September 30, 1980

, 1980
F Schmid, C P Khattak, Mustafa Basaran
openalex   +2 more sources

Portfolio risk reduction: Optimising selection of resources projects by application of financial industry techniques [PDF]

, 2001
Noll Moriarty
openalex   +1 more source