Results 31 to 40 of about 5,971 (229)
The relationship of prayer and internal religiosity to mental and spiritual well-being [PDF]
, 2004 Plan BThe purpose of this study was to explore the relationship between internal religiosity, including prayer, to well-being, which includes religious and existential well-being.
Gabler, William M.
core
Matroids with coefficients over projective planes
, 1994 Coordinatizing a projective plane Π by a Hall ternary field T and factoring out its extended radical Ra we obtain a fuzzy ring K = T//Ra in the sense of A. Dress which makes Π a matroid with coefficients in K.
Kalhoff, Franz
core +1 more source
Strong duals of projective limits of (LB)-spaces [PDF]
, 2002 summary:We investigate the problem when the strong dual of a projective limit of (LB)-spaces coincides with the inductive limit of the strong duals. It is well-known that the answer is affirmative for spectra of Banach spaces if the projective limit is a
J. Bonet +5 more
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Gorenstein Projective Precovers
, 2017 We prove that the class of Gorenstein projective modules is special precovering over any left GF-closed ring such that every Gorenstein projective module is Gorenstein flat and every Gorenstein flat module has finite Gorenstein projective dimension. This
Estrada, Sergio +2 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source