Results 31 to 40 of about 359,120 (311)
Projekt statutu i regulaminu archiwum diecezjalnego
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Stanisław Librowski
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Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
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Miroslav Kovačević rođen je 16. kolovoza 1945. u Osijeku. U Senju provodi djetinjstvo te završava osnovnu školu i gimnaziju. Poeziju pisanu književnim govorom objavljuje uvećini tadašnjih dječjih časopisa, a uvrštena je i u osnovnoškolske čitanke. Piše i
Helena Knifić Schaps
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Strategia poszukiwania pomysłów na projekt
Współczesny świat wykazuje coraz większy strumień zmian. Każda zmiana wprowadza do decyzji zarządczej nowy udział w niepewności, pojawieniu się.
Svitlana Ivanova +3 more
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
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Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
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Projekt jako metoda zarządzania – wyzwania i szanse dla administracji publicznej w Polsce
Celem artykułu jest przedstawienie wybranych rozwiązań zarządzania projektami w administracji publicznej, które nie wynikały z konieczności realizacji zadań związanych z zarządzaniem funduszami UE lub realizacji projektów współfinansowanych z tych ...
Jacek Cheda, Bartosz Rzętkiewicz
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Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
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