Results 41 to 50 of about 80,785 (214)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

OCHRONA ZABYTKOWYCH RUIN - PROBLEMY BADAWCZE I PROJEKTOWE NA PRZYKŁADZIE ZAMKU W SOCHACZEWIE

Ochrona Dziedzictwa Kulturowego, 2018
Badania historyczne ruin zamków, a następnie prace konserwatorskie - są procesem złożonym i wieloetapowym. W związku z zagrożeniem katastrofą ruin zamku w Sochaczewie Zespół Badań nad Polskim Średniowieczem, wykonał kompleksowe badania (historyczne ...
Maria Brykowska
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Les valeurs (in)différentes 
entre identité et image: le cas Trenitalia [PDF]

Ocula, 2015
Using the concepts of identity and values as a starting point, our paper introduces the example of the company Trenitalia to explain the differences between Corporate Identity and Corporate Image.
Michela Deni
doaj   +2 more sources

Humani generis unitas – projekt antyrasistowskiej encykliki Piusa XI

Kościół i Prawo, 2016
Artykuł jest poświęcony projektowi antyrasistowskiej i wymierzonej w antysemi­tyzm encykliki Piusa XI z 1938 r. Humani generis unitas. Tekst przedstawia kulisy powsta­wania projektu, stosunek Piusa XI do nazistowskich i faszystowskich represji wobec ...
Aleksandra Polewska
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Nastavnička percepcija projektnog učenja u području strukovnog tehničkog obrazovanja

Politehnika
Prema dosadašnjim iskustvima i analizama učenje temeljeno na projektima je vrlo slabo zastupljeno u srednjim školama Republike Hrvatske kao nastavna strategija u kurikulumima stručnih predmeta.
Dino Delač, Damir Purković
doaj   +1 more source

Participation of knowledge workers at the implementation of projects in Polish enterprises

Management, 2014
Dla krajów współczesnego świata, funkcjonujących w gospodarce globalnej, coraz bardziej ulotna staje się wizja kontynuowania dotychczasowych założeń gospodarczych w oparciu o założenia związane z dotychczasowym funkcjonowaniem.
Igielski Michał
doaj   +1 more source